Plant Transcription Factor Database
Previous version: v3.0
Brachypodium stacei
M-type_MADS Family
Species TF ID Description
Brast01G002800.1.pM-type_MADS family protein
Brast01G040100.1.pM-type_MADS family protein
Brast01G040100.2.pM-type_MADS family protein
Brast01G040300.1.pM-type_MADS family protein
Brast01G041200.1.pM-type_MADS family protein
Brast01G048500.1.pM-type_MADS family protein
Brast01G220100.1.pM-type_MADS family protein
Brast01G271500.1.pM-type_MADS family protein
Brast01G288700.1.pM-type_MADS family protein
Brast01G288800.1.pM-type_MADS family protein
Brast01G288900.1.pM-type_MADS family protein
Brast01G294000.1.pM-type_MADS family protein
Brast02G083800.1.pM-type_MADS family protein
Brast02G222300.1.pM-type_MADS family protein
Brast03G062800.1.pM-type_MADS family protein
Brast03G265300.1.pM-type_MADS family protein
Brast03G289700.1.pM-type_MADS family protein
Brast04G290700.1.pM-type_MADS family protein
Brast05G123100.1.pM-type_MADS family protein
Brast05G232100.1.pM-type_MADS family protein
Brast05G232200.1.pM-type_MADS family protein
Brast06G100300.1.pM-type_MADS family protein
Brast06G100500.1.pM-type_MADS family protein
Brast06G133300.1.pM-type_MADS family protein
Brast06G192500.1.pM-type_MADS family protein
Brast06G192600.1.pM-type_MADS family protein
Brast06G217900.1.pM-type_MADS family protein
Brast06G218100.1.pM-type_MADS family protein
Brast06G222900.1.pM-type_MADS family protein
Brast06G223000.1.pM-type_MADS family protein
Brast06G225400.1.pM-type_MADS family protein
Brast06G247300.1.pM-type_MADS family protein
Brast07G063900.1.pM-type_MADS family protein
Brast07G064000.1.pM-type_MADS family protein
Brast07G122000.1.pM-type_MADS family protein
Brast07G231800.1.pM-type_MADS family protein
Brast07G231900.1.pM-type_MADS family protein
Brast08G215200.1.pM-type_MADS family protein
Brast08G215400.1.pM-type_MADS family protein
Brast08G215500.1.pM-type_MADS family protein
Brast08G215700.1.pM-type_MADS family protein
Brast08G216000.1.pM-type_MADS family protein
Brast08G220600.1.pM-type_MADS family protein
Brast08G238100.1.pM-type_MADS family protein
Brast08G238200.1.pM-type_MADS family protein
Brast09G106700.1.pM-type_MADS family protein
Brast10G177900.1.pM-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513